Ibrahim Adamu
School of Health Sciences, Spring Valley College Of Health Sciences, Business and Technology, Zambia
Publications
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Review Article
Small Airway Physiological Signatures of Response to Biologic Therapy in Severe Asthma
Author(s): Ibrahim Adamu*
Severe asthma remains a major clinical challenge despite advances in biologic therapies. Small airway dysfunction (SAD) contributes substantially to persistent symptoms, exacerbation burden, and heterogeneous treatment responses. Despite emerging evidence, most available studies remain limited to single-center severe asthma biologic cohorts, underscoring the need for pooled international oscillometry datasets to develop more generalizable predictors of response variability. This systematic review synthesizes evidence on the role of small airway physiological biomarkers as predictors and monitoring tools for biologic therapy response in severe asthma. Literature published between 2016 and 2025 was systematically reviewed following PRISMA 2020 principles. Across included studies, impulse oscillometry (IOS) indices such as R5-R20 and AX, spirometric markers including FEF25-75%, and lung .. Read More»