Open Access Journal of Molecular Medicine(OAJMM)
Hussein Mussa Muafa
University for medical and applied sciences, Yemen
Publications
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Research Article
The Gut Microbiome's Influence on Extra- Intestinal Diseases: A Cross-Sectional Analysis of Neurological and Autoimmune Disorders
Author(s): Hussein Mussa Muafa* and Malika Abdu Balkam
The human gut microbiome, composed of trillions of microorganisms, plays a pivotal role in maintaining health and influencing disease processes far beyond the gastrointestinal tract. Disruptions in microbial balance, known as dysbiosis, have been increasingly associated with neurological and autoimmune conditions through complex interactions involving microbial metabolites, immune modulation, and neural pathways. This study investigated gut microbiome alterations in Alzheimer’s disease, Parkinson’s disease, rheumatoid arthritis, and systemic lupus erythematosus using a cross- sectional design involving 160 participants, including 120 patients and 40 matched healthy controls. Stool samples were analyzed by 16S rRNA gene sequencing on the Illumina MiSeq platform, with bioinformatic assessment conducted using the QIIME2 pipeline. Results showed pronounced dysbiosis in all pat.. Read More»