International Journal of Orthopaedics Research(IJOR)
ISSN: 2690-9189 | DOI: 10.33140/IJOR
Impact Factor: 1.6
Helena Maria Mendes Marques
Department of Orthopedics and Traumatology, SES-DF – Hospital Regional de Sobradinho, Distrito Feder, Brazil
Publications
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Research Article
Comparative Efficacy and Safety of Platelet-Rich Plasma Alone Versus Platelet-Rich Plasma Combined with Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review
Author(s): Eric Lorenzeto Cardoso, Thiago Cavalcante Ribeiro, Douglas de Melo Moura, Gabriel de Castro Monteiro, Helena Maria Mendes Marques, Gabriel Ricardo de Araújo Ruivo, Edward Rodrigues De Oliveira Filho, Frederico Tannus de Almeida, Sylvane Fernandes Santos Oliveira and Karollyne da Silva Morais
Background: Knee osteoarthritis is a prevalent degenerative joint disease characterized by pain, stiffness, functional limitation, and progressive impairment in quality of life. Intra-articular platelet-rich plasma (PRP) and hyaluronic acid (HA) are widely used conservative injectable therapies, and their combination has been proposed to integrate the biological effects of platelet-derived mediators with the viscoelastic and lubricating properties of HA. Objective: This systematic review aimed to evaluate the efficacy and safety of PRP alone compared with PRP combined with HA in patients with knee osteoarthritis, considering pain, physical function, stiffness, patient-reported outcomes, adverse events, and follow-up duration across available clinical studies. Methods: Clinical studies published in English between 2.. Read More»