Hajer Kilani
Research Laboratory LR99ES11, Biochemistry Department, Rabta University Hospital, Tunis, Tunisia
Publications
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Research Article
Biochemistry Characterization of Type 2 Diabetes in Tunisia and their Relationship with 4545G/C Polymorphism Located in Adiponectin Gene
Author(s): Hajer Kilani*, Ameni Kallel and Riadh Jemaa
Diabetes incidence is increasing worldwide. Many studies demonstrated that polymorphisms within the adiponectin gene could be associated with type 2 diabetes mellitus (T2DM). A case–control study was conducted to find the association between SNP 4545G/C and T2DM in Tunisian population. The study included 561 patients referring to diabetic and 437 healthy con- trols. DNA was extracted from blood and genotyped by PCR–RFLP by using (HinfI) enzyme. Prevalence of obesity (p <0.001), dyslipidemia (p <0.001), hypertension (p <0.001) were significantly increased in cases with report to witnesses. Also for the lipid parameters Urea, CRP and HDL-C were significantly (p <0.001) and HDL / LDL (p = 0.983) are decreased in diabetics compared to controls two types of alleles G (Absence of restriction site) and C (presence of the restriction site) respectively of frequencies (.. Read More»