Félix Porras
Longevity Medical Institute, San José del Cabo, Baja California Sur, Mexico Longevity Medical Institute, United States
Publications
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Research Article
Allogeneic Umbilical Cord Mesenchymal Stromal Cells for Knee Osteoarthritis: Systematic Review and Meta-Analysis of Controlled Injection Trials
Author(s): Kirk Sanford*, Félix Porras, Fergie Martínez, Hugo Ramos, Janine Zamitiz, Carlos Green and Edward Ramsay
Background Knee osteoarthritis is a leading cause of chronic pain and reduced mobility worldwide. Intra-articular corticosteroids and hyaluronic acid injections are commonly used, but many patients experience limited durability of symptom improvement. Allogeneic umbilical cord derived mesenchymal stromal cells (UC-MSCs) have emerged as a regenerative medicine strategy intended to modulate inflammation and improve clinical outcomes. Objective To evaluate controlled clinical trial evidence for intra-articular allogeneic UC-MSC therapy in symptomatic knee osteoarthritis, with emphasis on durability of pain improvement at 12 months. Methods A systematic review was conducted to identify controlled clinical trials evaluating intra-articular allogeneic UC-MSCs for knee osteoarthritis with comparator injection arms. The pr.. Read More»