International Journal of Diabetes & Metabolic Disorders(IJDMD)

Nakhoul F Nakhoul, Ophthalmology Division, the Tzafon Poriya Medical Center, Lower Galilee, and Azrieli Faculty of Medicine, Bar-Ilan University, Israel

Publications

• Research Article   
  Diabetic Retinopathy: Pathophysiology and New Pathways
  Author(s): Nakhoul F. Nakhoul* and Darawsha Mamdoh
  
  Diabetic retinopathy is one of the most common microvascular complications of diabetes mellitus, which is associated with damage of blood-retinal barrier and ischemia of retinal vasculature. Consequently, there is a decrease in visual acuity due to leakage of retinal vessels and aberrant pathological angiogenesis. Different studies have shown that autophagy & klotho proteins can plays an important role in the pathogenesis of DR, Type 2 diabetes mellitus, is associated with increased glucose cell toxicity and oxidative stress that can lead to irreversible damage in retina. Autophagy plays a critical role in degradation of damaged intracellular proteins to maintain intracellular homeostasis. The Klotho is a circulating anti-aging hormone with anti-oxidative and anti-inflammatory properties with vascular protective effects. The disturbance of autophagy and klotho pathways a.. Read More»
  

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