Advancements in Journal of Urology and Nephrology(AJUN)

Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, , Moulay Ismail University of Meknes, Morocco and EST Khenifra, Sultan Moulay Sliman University, Khenifra 23000, Morocco

Publications

• Research Article   
  Polyphenols from Prunus armeniaca.L as Promising Anticancer (Cervical Cancer): In silico studies and in vivo safety assessment
  Author(s): Moujane Soumia, Bouadid Ismail, Bouachrine Mohammed, Benlyas Mohamed, Filali Zegzouti Younes, Eddouks Mohamed and Moualij Benaissa*
  
  Some anogenital tract malignancies have high-risk human papillomavirus (HPV) infections as their etiological cause. Although many HPV preventative vaccines have been licensed, there is still a need for medication that targets the infection and its carcinogenic effects. One of the important elements in cell immortalization and tumor development in HPV-positive cells has been identified as the viral oncoprotein E6. The cellular ubiquitin ligase E6AP interacts with E6, which can facilitate the degradation of the tumor suppressor protein p53. One of the best ways to prevent the maintenance and growth of infected cells is to block the creation of the E6-E6AP complex. The present study aims to determine the ability of polyphenols identified in Prunus armeniaca.L, to target the HPV16 virus by virtual high-throughput screening and molecular docking, and to evaluate the safety of this plant in.. Read More»
  

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