Alexandre Havt
INCT-Biomedicina no Semiárido Brasileiro (INCT- Biomedicina), Núcleo de Biomedicina (NUBIMED), Facul, Brazil
Publications
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Research Article
Pre-Clinical and Randomized Clinical Trial with Bromhexine and N-Acetylcysteine for COVID-19
Author(s): Roberto J Pires Neto*, Marco Clementino*, Rafael F Mesquita*, Mariana S Lima*, Ronaldo B Martins, Iasmin Ferreira, Jose Quirino Filho, Rafhaella N D G Gondim, Lyvia M V C Magalhães, Karene F Cavalcante, Vania A F Viana, Liana P Mello, Jose KSouza, Xhaulla M Q C Fonseca, Armenio A Santos, Pedro J C Magalhães, Alexandre Havt, Erico A G Arruda, Juliano P Souza, Marjorie Pontelli, Italo A Castro, Thais M Lima, Rosa M M Viana, Daniel M Jorge, Priscyla D Marcato, Hugo P Monteiro, Eurico Arruda and Aldo A M Lima*
Treatment options for mild to moderate COVID-19 is limited. N-acetylcysteine and bromhexine have antiviral activity and show potential as treatment options against SARS-CoV-2 infections. This study evaluates the in vitro antiviral effect of bromhexine (BMX) for SARS-CoV-2 and determines the efficacy of treatment with BMX in combination with N-acetylcysteine (NAC) to reduce clinical scores in patients with mild to moderate COVID-19. Upon evidence from pre- clinical studies, a single center randomized trial of BMX + NAC (ClinicalTrials.gov Identifier: NCT04928495) with 420 participants in total took place in Fortaleza, CE, Brazil. Out of the 420 participants 140 received placebo, 140 received NAC alone, and 140 received NAC + BMX. Patients were monitored for 10-14 days, where physicians recorded all signs and symptoms reported. Nasopharyngeal swabs and blood samples were collected for S.. Read More»