International Journal of Clinical and Medical Education Research(IJCMER)

Department of Drug Science and Technology, University of Turin, Italy

Publications

• Research Article   
  Exploring the Binding Profiles of Natural Compounds and BTK Inhibitors: A Docking and Electrostatic Study
  Author(s): Alessandro Careglio*
  
  Bruton's tyrosine kinase (BTK) is a cytoplasmic, non-receptor protein tyrosine kinase crucial in B-cell signaling and a key target for treating hematological malignancies and inflammatory diseases. This study investigates the interactions between natural compounds and BTK inhibitors using computational docking and electrostatic complementarity analyses. We performed in silico docking studies with Flare Cresset, comparing known BTK inhibitors with compounds from various natural sources. Results indicate several natural compounds exhibit significant binding scores to BTK, suggesting potential as BTK modulators. Notably, Hypericum compounds showed high affinity for serum albumin, potentially leading to drug displacement. Additionally, quinone and anthraquinone compounds from species like St. John's wort, Rumex, and aloe demonstrated promising interactions with BTK. This research .. Read More»
  

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