International Journal of Clinical & Experimental Dermatology(IJCED)
ISSN: 2476-2415 | DOI: 10.33140/IJCED
Impact Factor: 1.9
Aleix Cuenca
Pharma & Medical Department, INDIBA SAU, 08174 Sant Cugat del Valles, Spain
Publications
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Research Article
Structural and Functional Synergistic Collagen-Based Formula: in Vitro Characterization and Clinical Evaluation of Dermatological Outcomes
Author(s): Aleix Cuenca*, Soto-Fernandez C, Iascu A., Bravo Y and Romero-Rueda J.
Introduction: Dermal fibroblasts senescence impairs collagen turnover and decreased hyaluronic acid (HA) levels increase dryness and weaken barrier integrity, contributing to skin aging. Hydrolyzed fish collagen has been shown to stimulate extracellular matrix (ECM) synthesis, promoting collagen synthesis and potentially reducing signs of aging. Aims: To characterize a synergistic formulation in vitro and assess its clinical effects on skin hydration and signs of ageing. Methods: Human dermal fibroblast proliferation was assessed after treatment with a nutraceutical mixture of active ingredients with expected synergistic effects, containing fish collagen and antioxidants, including HA, Coenzyme Q10, and Vitamin C (INDIBA Sicily Collagen). Type I and III collagen accumulation in the ECM was quantified by ELISA. Skin.. Read More»