Wheat Gluten Hydrolyzed Peptide Protection Joint Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

Abstract

Kang-ting Liao, Wei-Ting Hsieh, Yi-ming Liu, Dian-Hong Shen and Yu-Chin Lin

Background: Osteoarthritis is the most predominant joint disease, that has obsession millions of people. The purpose of this study was to evaluate the efficacy from natural plant source purifying the hydrolyzed wheat peptides (Vollapep2TM) for knee osteoarthritis (OA) pain and associated symptoms compared to placebo group.

Methods: The assessed have the change of Visual Analogue Scale (VAS) score, Western Ontario McMaster Osteoarthritis Index (WOMAC) and Traditional Chinese Medicine (TCM) syndrome classification, from baseline through 45 days between the Vollapep2TM and placebo groups.

Results: At 45 days, the Vollapep2TM group demonstrated a significant reduction in VAS score compared to placebo group. Supplementation with Vollapep2TM also resulted in significant changes for all three WOMAC subscales: pain the Vollapep2TM group and placebo group were reduction rate 93% and 80%, respectively; physical function the Vollapep2TM group and placebo group were reduction rate 73% and 53%, respectively; total WOMAC score the Vollapep2TM group and placebo group were reduction rate 87% and 67%, respectively. Another TCM syndrome classification the Vollapep2TM group can reduce joint pain, swollen, tenderness compared to the placebo group. Safety outcomes did not differ among the groups.

Conclusion: Vollapep2^TM group demonstrated can effectively reduce osteoarthritis, relieve joint swollen and tenderness, then elevate joint mobility and flexibility and improved quality of life.

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