The Warburg Effect in Cancer: Therapeutic Implications and Early Detection

Abstract

Aditya Banerjee, Dishari Ghosh, Rojina Khatun, Sudeshna Sengupta and Malavika Bhattacharya

The Warburg effect, a defining hallmark of tumor metabolism, is characterized by cancer cells' preference for aerobic glycolysis over oxidative phosphorylation. Once considered a curious anomaly, it is now recognized as a central driver of cancer progression, metastasis, and therapeutic resistance. Harnessing this metabolic vulnerability has paved the way for new strategies in oncology - from guiding prognostic biomarker development to enabling early detection through metabolic imaging. As researchers continue to explore and decode the complexities surrounding tumor bioenergetics, the Warburg effect stands at the forefront of next-generation cancer diagnostics and treatment.

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