Signal Transduction of Nerve Growth Factor Induced Histamine Secretion from Mast Cells

Abstract

Ilonka Ferjan*

Mast cells play a central role in allergic reactions. In response to immunologic or non-immunologic stimuli they release many inflammatory mediators. Biogenic amine, histamine is one of the essential mediator, which is relesed from mast cells during inflammation reactions. Nerve growth factor (NGF) is essetial for the survival of various neurones and has significant role in inflammation and allergic reactions. Histamine release from mast cells induced by NGF is strongly dependent on the concentration of extracellular Na+and Ca2+ ions. The studies of the role of different enzymes in NGF induced histamine relese have shown that tyrosine kinase, phosphatidylinositol-3-kinase, protein kinase C and phospholipase C are involved in the signal transduction responsible for NGF induced histamine secretion from mast cells. The right ionic composition of the extracellular fluid and the exact signaling pathway involved in NGF induced histamin secretion indicate the importance of NGF in various inflammatory and allergic deseases.

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