Pilot Human Test on the Effect of SugarLock® Peanut Skin Extract in Stabilizing Postprandial Blood Glucose Fluctuations

Abstract

Yung-Kai Lin, Yung-Hsiang Lin, Shu-Ting Chan and Chi-Fu Chiang*

Postprandial glucose fluctuation contributes to oxidative stress, inflammation, and metabolic disorders. Natural plant-derived ingredients that modulate carbohydrate digestion offer a safe nutritional strategy for glycemic control. SugarLock® peanut skin extract, rich in polyphenols and proanthocyanidins, may inhibit α-amylase and α-glucosidase activities and reduce glucose absorption. This pilot human test evaluated the efficacy of peanut skin extract in stabilizing postprandial blood glucose in healthy adults. A self-controlled crossover study was conducted in nine healthy subjects (aged ≥18 years). Each subject completed four test sessions-control (Taiwanese braised pork rice), SugarLock® (400 mg), mulberry leaf extract (250 mg), and white kidney bean extract (500 mg)—with a one-week washout interval between sessions. Capsules were taken 15 minutes before the meal, and glucose levels were continuously monitored for 3 hours using a CGM system. The results showed that pre-meal intake of peanut skin extract led to a lower postprandial glucose peak (113.8 mg/dL vs. 127.1 mg/dL for control) and a smaller percentage increase (24.1% vs. 34.9%) in AUC_0-3h. SugarLock® peanut skin extract attenuates postprandial glucose elevation and stabilizes glycemic response, suggesting potential as a functional ingredient for maintaining metabolic health.

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