Highly Agglutinative Staphylococcin Therapy for Malignant Pleural Effusions: A Systematic Literature Review and Meta analysis

Abstract

Likun Zan, Juyu Chen and Dongfeng Tan

Object: The purpose of our study was to evaluate the therapeutic effect and safety of highly agglutinative staphylococcin (HAS) intreatment of malignant pleural effusion (MPE). Materials and Methods: A computerized and manual search was performed of scientific studies published before October2016 in the electronic databases. Three categories of treatment comparisons underwent meta-analysis separately for therapeutic effects and safety.
Results: There sults showed that thetherapeutic effect of HAS plus chemotherapy was greater than that of chemotherapy alone (OR, 1.475; 95% CI, 1.14-1.909). The rate of fever was higher in patients treated with HASthan in those treated with lentinan/elemene (OR, 3.791; 95% CI, 1.346-10.687) or chemotherapy (OR, 6.528; 95% CI, 2.331-18.284). The results indicated that the symptom of fever may be a manifestation of HAS stimulating the immune system.
Conclusion: HAS combined with chemotherapy has a better therapeutic effect against MPE compared with chemotherapy alone.

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