Correlation between Urinary β2-MG Level in Renal Tubular Injury and Non-Free Posture

Abstract

Dao Zheng*

Objective: To observe and analyze the correlation between urinary β2 -MG levels and non-free position during renal tubular injury. Explored the possible mechanism of renal tubular injury caused by ipsilateral renal pelvis hydrostatic pressure.

Method: A prospective study was conducted on 85 randomly selected adults to explore the etiology of kidney stones. 75 patients in non-free position and 10 healthy volunteers in free position were randomly selected and grouped according to different sleeping positions. We collected morning urine separately. The levels of urinary β2 -MG were measured using radioimmunoassay. Among them, 24 patients in non-free position were randomly selected for a second urine test. The urine test method was the same, and the interval between the two urine tests was about one month. The urine test results of the same person twice before and after form a paired sample.

A database was established using SPSS 26.0 software and statistical analysis was conducted. Non parametric tests are used for continuous numerical variables that do not follow a normal distribution, while metric data with skewed distributions are represented by M (P25, P75). Mann Whitney U rank sum tests are used to compare differences between groups. The difference is statistically significant with P<0.05 (bilateral).

Result: In the non-free position group, 69 male subjects were randomly selected, with a median urinary β2 -MGlevel of 0.19 (0.16-0.33) MG. Four female participants were randomly selected, with a median urinary β2 -MGlevel of 0.13 (0.02-0.55) Mg. We conducted an independent sample Z-test on two sets of data, P>0.05. In the non-free position group, the median value of urinary β2 -MG levels in 75 randomly selected patients was 0.19 (0.16-0.33) Mg. The median value of urinary β2 -MG levels in 10 randomly selected patients in the free position group was (0.19 (0.16-0.22) Mg. We conducted an independent sample Z-test on two sets of data, P<0.05. There are 75 research subjects in the observation group, of which 51 did not undergo a second urine test; 24 cases underwent two urine tests. This article conducted a paired sample Z-test on the results of two urine tests. The results showed that among them, the median value of the second urineβ2 -MG level was higher than the first urine test result in 12 patients who continued to adhere to non-free position for about a month, and the difference was statistically significant [0.28 (0.09-0.44) mg/L vs. 1.105 (0.45-1.41) mg/L, Z=-3.059, P=0.002];And in the other 12 patients, after about a month of transitioning to a free position, the median value of urine β2 -MG levels in the second urine test was lower than that in the first urine test, and the difference was statistically significant [0.36 (0.25-0.65) mg/L vs. 0.19 (0.15-0.20) mg/L, Z=-3.059, P=0.002].

Conclusion: The study found that non free position is closely related to the median value of urinary β2-MG levels. Tip: Non free position is closely related to impaired renal tubular reabsorption function. The renal tubular injury and changes in urine composition caused by non-free position may be related to the formation of kidney stones. Free position helps prevent kidney stones.

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