Changing Sensitivity Pattern of Pseudomonas Species- A 5-year Study at a Tertiary Care Hospital
Abstract
Muhammad Moaaz Ali, Hafiz Muhammad Hamza, Abeer Inayat Ullah, Muhammad Daoud Tariq, Mohammad Iftikhar Ahmed Manzoor, Areeba Ahsan, Fatima Kaleem and Shahid Ahmed Abbasi
Purpose: Pseudomonas aeruginosa is a Gram-negative opportunistic organism known for its ability to cause serious infections, particularly in immunocompromised individuals. The development and dissemination of antimicrobial resistance in Pseudomonas aeruginosa have become a significant global health concern. The study aims to investigate the antimicrobial sensitivity patterns of Pseudomonas aeruginosa over the past five years in a tertiary care setting.
Methods: A comprehensive retrospective analysis was conducted using clinical data from a tertiary healthcare setting spanning five years (2018-2022). Isolates of Pseudomonas aeruginosa obtained from various clinical specimens were included in the study. Standardized procedures were used to perform the antimicrobial susceptibility tests, and the relevant statistical techniques were applied to analyze the data.
Results: A total of 1888 Pseudomonas aeruginosa isolates were included in the study. The study revealed an increasing trend in antimicrobial resistance among Pseudomonas aeruginosa isolates over five years. The most significant resistance was observed against commonly used antibiotics such as carbapenems, fluoroquinolones, and aminoglycosides.
Conclusion: This comprehensive analysis of Pseudomonas aeruginosa antimicrobial susceptibility patterns over the past five years emphasizes the increasing concern about antibiotic resistance in clinical settings. The rising resistance rates, particularly against essential antibiotics, underscore the urgent need for effective antimicrobial stewardship programs and the development of alternative therapeutic approaches to combat Pseudomonas aeruginosa infections. This study offers significant perspectives on the dynamic landscape of antibiotic resistance, empowering medical practitioners to make knowledgeable choices about the most suitable treatment plans for Pseudomonas aeruginosa infections. Keywords: Pseudomonas aeruginosa, antibiotic resistance, nosocomial infections, changing pattern, opportunistic pathogen.