Benzoate Drugs for Traumatic Brain Injury

Abstract

Swarupa Pahan and Kalipada Pahan

Traumatic brain injury (TBI) is an acute disorder with prolonged complexities that affirm to be the leading cause of deaths and disabilities in US. The pathophysiology of TBI comprises of multiple complex processes. An impactful insult results in tissue damage, neuroinflammation, impaired cerebral blood flow, BBB disruption, and demyelination, leading to neurodegeneration and functional impairments. There are no specific treatments for TBI. Recent studies highlight the potential efficacy of the following benzoates for attenuating TBI pathologies in rodents:

• Sodium benzoate, a metabolite of cinnamon, a widely used food additive and a Food and Drug Administration (FDA)-approved drug for glycine encephalopathy

• Glyceryl tribenzoate, FDA-approved flavoring element being used in food and food packing productions

In this review, we have made a genuine attempt to evaluate the significance of these two benzoates as prospective therapeutic options for TBI

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