Toxicology and Applied Pharmacology Insights(TAPI)

Department of Clinical Pharmacy and Pharmacy Administration, Bauchi State University Gadau, Bauchi S, Nigeria

Publications

• Research Article   
  Evaluation of Sedative Activity of Methanol Leaf Extract of Ceiba Pentandra Linn (Malvaceae) Using Mice
  Author(s): Stella Makuo Ubah, Abdullahi Haruna Yaro, Suleiman Yunusa* and Yahaya Mohammed Katagum
  
  Background: Insomnia and other associated disorders have been traditionally managed using leaves of Ceiba pentandra (Malvaceae). Methods: In this study, sedative and anxiolytic properties of methanol leaf extract of Ceiba pentandra using mice were evaluated. Acute toxicity study and phytochemical screening of the extract were also determined using standard protocols. The sedative effect of the extract was evaluated using Diazepam and ketamine- induced sleep, hole board test and mouse beam walk assay, whereas the anxiolytic activity was studied using open field, elevated plus maze and elevated stair case tests. Results: The intraperitonial LD50 of the methanol leaf extract of Ceiba pentandra was estimated to be 2150 mg/kg body weight in mice. Preliminary phytochemical screening of the extract revealed the positive r.. Read More»
  

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