Journal of Traditional Medicine & Applications(JTMA)

Department of Pharmacy Practice, ISF College of Pharmacy, India

Publications

• Research Article   
  Bridging Cytoskeletal and Epitranscriptomic Mechanisms: L-DOPA–Induced Microtubule Remodelling Meets m6A RNA Methylation in Neural Disorders
  Author(s): Sonu Kumar*
  
  Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss, α-synuclein aggregation, and disrupted motor and non-motor function [1]. Pharmacological replenishment of dopamine using L-3,4- dihydroxyphenylalanine (L-DOPA) remains the cornerstone of PD management; however, long-term exposure frequently induces motor fluctuations, dyskinesias, and cognitive side effects [2]. Recent mechanistic evidence reveals that L-DOPA itself, independent of its metabolic conversion to dopamine, can be aberrantly incorporated into neuronal microtubules, leading to structural and synaptic instability [3]. L-DOPA acts as a tyrosine analogue within the tubulin tyrosination–de–tyrosination cycle, where tubulin tyrosine ligase (TTL) catalyses its attachment to α-tubulin. The resulting L-Dopa–modified microtubules resis.. Read More»
  

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