Toxicology and Applied Pharmacology Insights(TAPI)

Visiting Fellow, School of Life, Health and Chemical Sciences, The Open University,, United Kingdom

Publications

• Research Article   
  Purine Quadruplexes Stabilised by a Modified Porphyrin Analogue have Implications for mRNA Viral Replication
  Author(s): Simon Chapman*
  
  Recent research has clearly demonstrated that suppression of replication in mRNA viruses may be possible by stabilising viral guanine quadruplexes (G4s). Whilst it has been previously only proposed that G4s could fold in the SARS- CoV 2 genome, research confirming their definitive presence has since been published. A suggestion was made that polyadenylation of SARS-CoV 2 might allow adenine quadruplexes (A4s) to fold as the necessary sequence was available. The quadruplex topology appeared relatively stable. This further implies that there is potential for purine quadruplexes to compromise the viral replication mechanism by improved stability. A4s in this scenario could compromise effective functions in the poly(A) tail. However, whilst telomestatin and pyridostatin stabilise G4s, both are large molecules and are not approved in general use. Furthermore, both have poor solubility and .. Read More»
  

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