Sedigh Bashir
Libyan Biotechnology Research CenterL, Libya
Publications
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Research Article
Advancing Precision Drug Therapy in Pregnant Women: PBPK Modeling of Antiviral Drugs
Author(s): Mohamed Abdulsamed*, Ashraf A Naass, Mohamed S A Eswani, Mohamed O Elbasir and Sedigh Bashir
PBPK/PD modeling is essential in modern drug development. Traditional drug development methods frequently rely on trial and error, which can be time-consuming, costly, and could be risky. Predicting pharmacokinetics (PK) of drugs in pregnant women, encompassing the intricate aspect of placental drug transfer, remains a complex task. This study was to compare of simulated or predicted and observed (previously published approaches) pharmacokinetic parameters among the four antiviral drugs in pregnant and non-pregnant women. In addition, this investigation endeavors to construct and assess physiologically-based pharmacokinetic (PBPK) models specific to maternal-fetal interactions for four antiviral drugs, Acyclovir, Emtricitabine, Dolutegravir (DTG) and Raltegravir (RAL). PBPK models were built with the Open Systems Pharmacology software suite (PK-Sim/MoBi). Different approaches to infor.. Read More»