Advances in Bioengineering and Biomedical Science Research(ABBSR)

Institute of Regenerative Education Plano, Texas, USA

Publications

• Research Article   
  Is the Foundation of Regenerative Orthobiologics and Aesthetics Built on Mechanistic Manipulation?
  Author(s): Scott M. Martin*
  
  Orthobiologic and aesthetic biostimulatory injectables hold a privileged regulatory and commercial position in the orthobiologic and aesthetic injectable markets. Most common amongst these injectable products are Platelet-Rich Plasma (PRP), Bone Marrow Aspirate Concentrate (BMAC), Calcium Hydroxylapatite (CaHA; Radiesse®), and Poly-L-Lactic Acid (PLLA; Sculptra®). Currently, PRP qualifies for Investigational New Drug (IND)-exempt Randomized Controlled Trial (RCT) access as a minimally manipulated, homologous-use autologous biologic. CaHA and PLLA have received FDA clearance for aesthetic applications largely due to mechanistic claims of neocollagenesis and fibroblast biostimulation. BMAC has widespread off-label clinical usage due to clinical literature claims of mechanistic growth-factor and mesenchymal stem cell presence. The purpose of this perspective review is to highligh.. Read More»
  

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