Journal of Biotechnology and Bioinformatics(JBB)

Universidade do Porto, Portugal

Publications

• Research Article   
  The Multifactorial Determinants of Tuberculosis Mortality: A Global Comprehensive Epidemiological Analysis and Framework for Disease Elimination
  Author(s): Richard Murdoch Montgomery*
  
  This study presents a comprehensive analysis of tuberculosis (TB) epidemiology, with particular emphasis on elucidating the determinants that differentiate TB infection from fatal outcomes. Through systematic examination of demographic, clinical, socioeconomic, and healthcare system factors, this research illuminates the complex, multifactorial nature of TB mortality. Our findings demonstrate pronounced disparities in mortality across age demographics, with individuals above 55 years experiencing disproportionately elevated fatality rates (case-fatality ratio nearly three times that of younger adults, p<0.001) despite peak incidence occurring in younger cohorts. Clinical comorbidities, particularly HIV co-infection (45% mortality rate; RR 3.0, 95% CI 2.8-3.2), malnutrition (62% mortality rate), and drug resistance (37% mortality rate), emerged as significant mortality risk modifier.. Read More»
  

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