Journal of Electrical Electronics Engineering(JEEE)
ISSN: 2834-4928 | DOI: 10.33140/JEEE
Impact Factor: 1.2
Peter Idoko
Department of Electrical Electronic Engineering, Faculty of Technology, University of Ibadan, USA
Publications
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Research Article
An Organic Field-Effect Transistor-Based NANOFLEX-BIOCHIP for Ultrasensitive and Rapid Detection of HBV and HIV Biomarkers Using Atangana-Baleanu-Caputo Fractional-Order Modeling
Author(s): Christian Idogho* and Peter Idoko
Early and accurate detection of viral infections remains a major challenge in global healthcare, particularly for Hepatitis B virus (HBV) and Human Immunodeficiency Virus (HIV), where biomarker concentrations during early infection fall below the detection limits of conventional diagnostic assays. Here, we report the design, fabrication, and experimental validation of an organic field-effect transistor (OFET)-based NanoFlex-BioChip for ultrasensitive and rapid detection of hepatitis B surface antigen (HBsAg) and HIV-1 p24 antigen. The device employs a bottom-gate, top-contact architecture based on solution-processed poly(3-hexylthiophene) (P3HT) and a selectively biofunctionalized interface with covalently immobilized antibodies. Biomolecular binding induces electrostatic gating of the semiconductor channel, resulting in measurable threshold voltage shifts of up to 0.5 V and a 15&ndas.. Read More»