Nanak Singh Toor
Department of Pharmacy Practice, ISF College of Pharmacy, India
Publications
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Research Article
Structural and Functional Mapping of the Human β-Globin Gene Cluster on Chromosome 11: Insights from Somatic Cell Hybridization and Molecular Hybridization Approaches
Author(s): Sonu Kumar*, Jashan Jindal, Mohd Haneef, Nanak Singh Toor and Khadga Raj Aran
The systematic mapping of the human β-globin gene cluster on chromosome 11 has provided a seminal framework for understanding chromosome structure–function relationships and regulatory logic in the human genome [1]. Early cytogenetic and molecular investigations demonstrated that the γ-, δ-, and β-globin genes localize to the distal short arm of chromosome 11 (11p15.5), a region enriched in developmentally regulated gene clusters and long-range cis-regulatory elements, including the locus control region (LCR), which mediates stage- and tissue-specific globin transcription [2]. Somatic cell hybrid mapping, using complementary Chinese hamster × human and mouse × human hybrid systems, enabled progressive refinement from whole-chromosome assignment to arm- and band-level localization, establishing that retention of 11p is necessary and sufficient fo.. Read More»