International Internal Medicine Journal(IIMJ)

Prince Sattam Bin Abdulaziz University, Preparatory Year Deanship, Basic Science Department, Saudi Arabia

Publications

• Research Article   
  Mitochondrial Epitranscriptomics: The Role of RNA Modifications in Cellular Energy Regulation and Aging
  Author(s): Mohammad Ahmad Ahmad Odah*
  
  Background: Mitochondria play a crucial role in cellular metabolism and energy production. While traditionally studied through nuclear and mitochondrial DNA regulation, recent research highlights the significance of post- transcriptional modifications in mitochondrial RNA (mtRNA). These modifications influence mitochondrial gene expression, energy balance, and aging. Understanding mitochondrial epitranscriptomics—specifically modifications like N6-methyladenosine (m6A), pseudouridylation, and 5-methylcytosine (m5C)—is essential for uncovering their impact on cellular function and disease. Objective: This review aims to explore the emerging field of mitochondrial epitranscriptomics, analyzing key RNA modifications, their roles in oxidative phosphorylation (OXPHOS) and reactive oxygen species (ROS) regulation, and their implication.. Read More»
  

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