Journal of Traditional Medicine & Applications(JTMA)
ISSN: 2833-1389 | DOI: 10.33140/JTMA
Impact Factor: 1.02
Mazhuvancherry Unnikrishnan
Department of Pharmacology, MCOPS, Manipal, India
Publications
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Research Article
Integrated in-Vitro and in-Vivo Evaluation of the Ethyl Acetate Fraction of Basella Alba Against Aflatoxicin B1- Induced Hepatocellular Carcinoma
Author(s): Gaddam Dayanand Reddy*, Ramaswamy Kartik, Chandana Venkateshwara Rao, Mazhuvancherry Unnikrishnan, T Varalakshmi and Palpu Pushpangadan
Aflatoxin B1 (AFb1) is known to be a strong hepatocarcinogen, and hepatocellular carcinoma (HCC) continues to be one of the main causes of cancer-related death globally. The current work used integrated in-vitro and in-vivo methods to assess the ethyl acetate fraction of Basella alba (B alba) anticancer and hepatoprotective capabilities against AFb1- induced hepatocellular carcinoma. Standard cell viability, apoptosis, and oxidative stress tests were used to evaluate the ethyl acetate fraction's in vitro cytotoxicity and antiproliferative properties in human hepatocellular carcinoma cell lines. Strong anticancer efficacy was indicated by the fraction's dose-dependent suppression of cancer cell proliferation, induction of apoptosis, and notable decrease in reactive oxygen species. AFb1 was used to produce hepatocellular cancer in experimental rats for in vivo assessment. By exa.. Read More»