Advances in Bioengineering and Biomedical Science Research(ABBSR)
ISSN: 2640-4133 | DOI: 10.33140/ABBSR
Impact Factor: 1.7
Maryam Nasirian
ntegrative functional gastroenterology Research Center, Isfahan University of Medical Sciences, Isfa, Iran
Publications
-
Research Article
An Analysis and Survey on Interleukin-10 Receptor Mutation in Inflammatory Bowel Disease in Iranian IBD Cohort
Author(s): Razieh Khoshnevisan, Nioosha Nekooie Marnany, Peyman Adibi, Hamid Tavakoli, Hossein Saneian, Mohammad hassan Emami, Maryam Nasirian, Somayeh Najaf, Majid Yaran, Soodabeh Rostami, Daniel Kotlarz, Christoph klein, Fariba Vakili, Abbas Rezaei, Roya Sherkat* and Mahdieh Behnam
Background: Early-onset inflammatory bowel disease (IBD) is classified to Crohn’s disease, ulcerative colitis and unclassified disorders which have chronic, relapsing course and can result in substantial long-term morbidity. IBD is a multifactorial disorder with genetic susceptibility, immunological predisposition and environmental triggers. Objective: To generally determine prevalence of IL10R mutation in IBD patients in Iran-Isfahan, we performed sequencing of all exons in IL10RA and IL10RB in cohort of IBD patients and healthy control. Material and Method: Total DNA content of 76 patients and 50 healthy controls were extracted from whole blood and PCR amplification and sequencing was done. Result: Overall identified IL-10RA mutations were P.(I224V), P.(A153V), P.(A153A), P.(S159G), P.(R26.. Read More»