Journal of Clinical & Experimental Immunology(JCEI)

Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, USA

Publications

• Research Article   
  Corrected Version: IL-12 p40 Monomer is Different from Other IL-12 Family Members to Selectively Inhibit IL-12Rβ1 Internalization and Suppress EAE
  Author(s): Susanta Mondal, Madhuchhanda Kundu, Malabendu Jana, Suresh B. Rangasamy, Khushbu K. Modi, Roumen Balabanov and Kalipada Pahan*
  
  Multiple sclerosis (MS) is the most common human demyelinating disease of the CNS. The IL-12 family of cytokines has four members which are IL-12 (p40:p35), IL-23 (p40:p19), the p40 monomer (p40), and the p40 homodimer (p402). Since all four members contain p40 in different forms, it is important to use specific monoclonal antibody (mAb) to characterize these molecules. Here, by using such mAb, we describe selective loss of p40 in serum of MS patients as compared to healthy controls. Similarly, we also observed decrease in p40 and increase in IL-12, IL-23 and p402 in serum of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, as compared to control mice. Interestingly, weekly supplementation of mouse and human recombinant p40 ameliorated clinical symptoms and disease progression of EAE. On the other hand, IL-12, IL-23 and p402 did not exhibit such inhibi.. Read More»
  

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