Archives of Case Reports: Open Access(ACROA)

Department of Neurosurgery, University of Pretoria, Steve Biko Academic Hospital, South Africa

Publications

• Case Report   
  The Potential Complementary Role of Imaging with 68Ga[68Ga-RGD] PET and MRI in Recurrent Adult Glioma
  Author(s): Tebatso MG Boshomane*, Kgatle M Mankgopo, Febin Joseph, Meshack Bida, Llewellyn Padayachy, Mariza Vorster and Mike M Sathekge
  
  Imaging of low (LGG) to high (HGG) grade gliomas is conventionally performed with MRI, which is the non-invasive gold-standard imaging modality to derive data. Gliomas (Grade1,2,3,4) are lethal and demonstrate poor outcomes despite novel therapies. Integrins compose of heterodimeric parasympathetic nervous system; the aVb3 (RGD i.e. Galacto-Arginine-GlycineAspartic acid) have been displayed as a potential biomarker that can be imaged via PET in order to trace the angiogenic pathway. Gliomas are common primary central nervous system (CNS) tumours which are often pose a diagnostic challenge, even to stage and manage because of their heterogeneity in molecular aberrations. Several core mutational core hallmarks of gliomas are inducing/accessing vasculature, tumour promoting inflammation, polymorphic microbes and avoiding/resisting cell death; these ultimately lead to poor prognosis. In 2.. Read More»
  

  Abstract HTML PDF