Toxicology and Applied Pharmacology Insights(TAPI)

Aretaieion University Hospital,Athens, Greece

Publications

• Research Article   
  The Influence of Statins on Bone Tissue in Ovariectomized Rats
  Author(s): Seferos N, G Rallis, Tesseromatis and Kotsiou A*
  
  Objectives: Osteoporosis is a silent, progressive, systemic skeletal disease characterized by impaired bone architecture with decreased bone mass density, affecting mainly women. Statins, inhibitors of HMG-CoA-reductase, seem to interfere with bone formation exerting anabolic and anti-resorptive effect. The aim of the present study is to investigate the effect of simvastatin on size parameters and bone density of mandible and femur, in an ovariectomized rat model of osteoporosis. Methods: 50 Wistar female rats were randomized in five groups (n=10). Groups 1, 2,3 were ovariectomized, 4 and 5 serve as controls. Groups 2, 3 and 5 were treated with simvastatin (0.5mg/kg/daily per os). Size parameters of the isolated femur, mandible and uterus, BMD via dual energy X-Ray absorptiometry (DEXA) and serum interleukin-13 (IL-13) were estimated. .. Read More»
  

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