Advances in Hematology and Oncology Research(AHOR)

Department of Medicine, Adachi Medical Center, Tokyo Women’s Medical University, Japan

Publications

• Case Report   
  Refractory Myeloma Developed with Multiple Extramedullary Tumors and Myelofibrosis
  Author(s): Toshie Ogasawara*, Shoko Marshall, Hiroshi Kazama, Kiyotaka Kawauchi and Tetsuya Ogawa
  
  The use of novel drugs has improved prognosis in multiple myeloma (MM). However, as the pathophysiology of primary Extramedullary Myeloma (EM) is not well defined due to its rarity, effective treatment for EM is not yet established. We report the case of a 63-year-old man with MM who presented with back pain and fever following the development of extramedullary disease, including subcutaneous tumors accompanied by marrow fibrosis. CT at presentation revealed subcutaneous tumors, mediastinal lymphadenopathy, and pleural involvement with pleural effusion. Peripheral blood exhibited leukoerythroblastosis. Bone marrow biopsy showed diffuse fibrosis and infiltration of large or small atypical cells with high N/C ratio that did not resemble plasma cells, and were positive for CD138 and cytoplasmic IgG/κ immunoglobulin. Biopsy of subcutaneous tumors showed an infiltration of small atyp.. Read More»
  

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