Journal of Traditional Medicine & Applications(JTMA)

Mile High Labs Inc., Department of Research and Development, USA

Publications

• Research Article   
  L-Theanine Amino Acid Thermo-Oxidative Degradation Kinetics in Acidic Formulations for Shelf-Life Prediction Using the Arrhenius Equation
  Author(s): Vardan Ter-Antonyan*, Casey Kikendall, Christopher Harris and John Davis
  
  The amino acid L-theanine is frequently used in dietary supplements and nutraceutical foods and beverages for its ability to modulate brain activity and neurotransmitter levels. The instability of this compound in acidic formulations (pH 2-3) is concerning and impactful for both product efficacy and shelf-life. This study investigates the thermo-oxidative degradation kinetics of L-theanine over 8 weeks in two formulations (F1 and F2) stored at 4, 25, and 40 °C under low relative humidity (<40%) and acidic conditions (pH 3.2 for F1 and 2.4 for F2). The degradation rate constant (k), activation energy (Ea ), molecular vibration frequency factor (A), and half-life (τ1/2) for each formulation were estimated from concentration-time data using a first-order kinetic model and the Arrhenius equation. Kinetic constants were derived by χ2 minimization, considering the measurement.. Read More»
  

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