International Journal of Women's Health Care(IJWHC)

Institut Perubatan dan Pergigian Termaju, Universiti Sains, Malaysia

Publications

• Research Article   
  P53 Gene Mutation Associated With Worse Clinicopathological Characteristic in Breast Cancer
  Author(s): Fitreena Anis Amran*, Imran Abdul Khalid and Badrul Hisyam Yahaya
  
  Background: P53 is a tumour suppresor gene. In breast cancer, p53 gene mutation were noted with frequency of about 30% (range 15 to 71%) and associated with poor prognosis. This study was performed to determine p53 mutation association with clinicopathological characteristic in breast cancer and to assess the suitability of patients’ serum to detect p53 autoantibody. Methods: This study conducted in Hospital Seberang Jaya and Institut Perubatan dan Pergigian Termaju, Universiti Sains Malaysia. Sixty-four breast cancer patients with available fresh breast cancer tissue that been kept under -80°C and with complete clinicopathological, data involve in this study. These fresh breast tissues DNA extracted and 10sampels sent for DNA sequencing. The remaining 54samples proceeded with Polymerase Chains Reaction analysis based on the result.. Read More»
  

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