International Internal Medicine Journal(IIMJ)

Institute of Translational Pharmacology, Consiglio Nazionale delle Ricerche, Rome, Italy

Publications

• Research Article   
  Polydatin in Cancer Research: Molecular Docking with UXS1 and Safety Profile Evaluation
  Author(s): Ivan Vito Ferrari* and Giampietro Ravagnan
  
  Polydatin, a polyphenolic compound sourced from various natural origins, has garnered attention also due to its potential anti-tumor properties and low toxicity. This research utilized Molecular Docking methods to investigate the molecular interactions between Polydatin and the Crystal Structure of Human UDP-glucuronic acid decarboxylase (UXS1), aiming to uncover the mechanisms contributing to its anti-tumor effects. The results as revealed a substantial binding energy value of approximately -10 kcal/mol for the Polydatin-UXS1 interaction, indicating a robust and favorable binding. This suggests that Polydatin holds significant promise in cancer research, offering insights into its ability to interact with and potentially modulate the activity of UXS1. Moreover, the additional step of predicting toxicity properties using the pKCSM server provides valuable insights into the safety prof.. Read More»
  

  Abstract HTML PDF