International Journal of Preventive Medicine and Care(IJPMC)
ISSN: 2994-032X | DOI: 10.33140/IJPMC
Charlotte Hartig-Andreasen
Department of Orthopedic Surgery, Aarhus University Hospital, Denmark
Publications
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Research Article
Increased Occupational Exposure to Physical Stress in Wild-Type Transthyretin Amyloid Cardiomyopathy – A Potential Disease Promoting Mechanism?
Author(s): Valentin Rosenkrans Klarskov, Bertil Thyrsted Ladefoged, Anders Lehmann Dahl Pedersen, Charlotte Hartig-Andreasen and Steen Hvitfeldt Poulsen*
Background: The cause of wild-type transthyretin amyloidosis cardiomyopathy (ATTRwt) remains unknown, with mechanical stress being hypothesized as a potential mechanism. No study has investigated the potential impact of occupational physical exposure on ATTRwt development. Methods: We enrolled 100 participants, including 50 ATTRwt patients with prior carpal tunnel syndrome surgery (CTS), 25 ATTRwt patients without CTS, and 25 age- and gender-matched stable heart failure patients with reduced ejection fraction (HFrEF) as controls. We evaluated self-reported physical work exposure, Danish occupation classification (DISCO-88), history of orthopedic joint-related disorders beyond CTS surgery, hand volumes, and physical status using the Kansas City Cardiomyopathy Questionnaire. Results: ATTRwt patients ha.. Read More»