Bruce H. Knox
Independent Scholar, New Zealand
Publications
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Research Article
Cumulative Autonomic Injury and Secondary Multifactorial Dysautonomia: A Lived Case Integrated with a Central Autonomic Regulatory Model
Author(s): Bruce H. Knox*
Background: Dysautonomia arising from cumulative physiological insult remains poorly characterised, particularly when involving both chronic post-viral injury and acute cardiovascular trauma. Objective: To integrate a lived patient narrative with a physiologically grounded model of central autonomic dysregulation and long-term recovery. Methods: A longitudinal first-person clinical narrative is combined with a structured three-layer autonomic model and supported by current literature in autonomic neuroscience and cardiovascular physiology. Results: The clinical presentation is best explained by central autonomic dysregulation with impaired gain control rather than structural autonomic failure. A three-hit framework—post-viral priming, cardiac tamponade, and surgical insult—acc.. Read More»