Bruce H Knox
Independent Scholar, Auckland, New Zealand
Publications
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Review Article
When Evidence is Absent: The Centrality of Data in Medical Decision-Making and the Consequences of Its Deficiency
Author(s): Bruce H Knox*
Modern medicine is fundamentally an evidence-driven enterprise, where clinical decisions are expected to rest upon robust, reproducible data [1,2]. Yet, in many areas of practice—particularly rare diseases, emerging conditions, and complex multi-system disorders—clinicians and patients must navigate uncertainty in the absence of clear evidence [3,4]. This paper examines the critical role of data in informing medical decision-making and explores the clinical, ethical, and psychological consequences that arise when such data are incomplete, inconsistent, or entirely lacking [5]. It argues that absence of data does not equate to absence of disease, but rather represents a structural gap within medical knowledge systems [6]. Addressing these gaps requires not only improved research infrastructure but also a reframing of how lived experience, clinical judgment, and adaptive rea.. Read More»

