Journal of Applied Surface Science(JASS)

Insight Research Ireland Centre for Data Analytics, Department of Computer, Science and Information Technology, University College Cork (UCC), Cork City, Ireland, European Union, Ireland

Publications

• Research Article   
  Reinventing Paracetamol through Prodrug Design: A Glycosylated β-D-Glucoside with Superior Solubility and Formulation Potential
  Author(s): Basker Palaniswamy*
  
  Many medicines do not dissolve well in water, which can limit how quickly and effectively they work. One proven way to improve this is to attach a natural sugar molecule to the drug. In this study, we investigate paracetamol β-D-glucoside (C14H19NO7 ), a modified form of paracetamol in which glucose is chemically linked to the drug through a β-glycosidic bond. This simple molecular change increases water solubility by 6–8 times compared to regular paracetamol, allowing faster dissolution and more flexible liquid formulations. The sugar–drug link is stable under normal body conditions but breaks apart under specific environments. At neutral pH (similar to blood), the compound remains highly stable, with a half-life exceeding 1000 hours at 25 �?� C. Under acidic conditions similar to the stomach (pH 2, 37 �?� C), it breaks down within minutes, rel.. Read More»
  

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