Andreea Mihaela Banta
"Victor Babes" University of Medicine and Pharmacy, Timisoara, 300041, Romania
Publications
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Research Article
Assesses of Chronic Lymphocytic Leukemia Cases with Isoform P53 Protein Using Elisa Method
Author(s): Ioan Ovidiu Gheorghe, Aurelian Udristioiu and Andreea Mihaela Banta*
Background P53 gene mutation is a very common event in human neoplasia, and genetic mutations in the P53 gene in a single allele are responsible for a hereditary cancer susceptibility syndrome (Li Fraumeni). These variants encode distinct isoforms of the p53 protein, which may disrupt its transcriptional activity. These point mutant proteins are more stable than the normal protein and the mutant product accumulates at a high level that allows obtaining important information about p53 gene expression in malignant cells, especially in Chronic Lymphocytic Leukemia, (CLL). By Enzyme Linked Immune-Absorbent Assay method, (ELISA), was analyzed the frequency of p53 protein expression to 20 eligible patients diagnosed with CLL for to investigate the relationship of this protein in the stages of the disease and the impact on treatment response and survival. In ELISA technique .. Read More»