Medicine & Pharmacology: Open Access(MPOA)

N.D. Zelinsky Institute of Organic Chemistry, 47 Leninsky Prospect, Russia

Publications

• Research Article   
  Rigid Adamantane and Cubane Scaffolds as Xenobiotic Frameworks in Medicine
  Author(s): Valery M. Dembitsky* and Alexander O. Terentev
  
  Rigid hydrocarbon scaffolds play an increasingly important role in modern medicinal chemistry by enabling precise control over molecular geometry, lipophilicity, and target interactions. Adamantane and cubane represent two paradigmatic rigid frameworks with distinct structural and physicochemical characteristics that are highly relevant to computer-aided drug design. Adamantane is a low-strain diamondoid scaffold extensively employed in clinically approved drugs, whereas cubane is a highly strained cubic hydrocarbon that serves as a three-dimensional bioisostere of benzene and offers unique opportunities for molecular innovation.This review provides a comparative analysis of natural adamantane-containing metabolites, synthetic adamantane derivatives, and fully synthetic cubane-based compounds, with a particular focus on computer-aided prediction of biological activity and structure&nd.. Read More»
  

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