Medicine & Pharmacology: Open Access(MPOA)

N.D. Zelinsky Institute of Organic Chemistry, 47 Leninsky Prospect, Russia

Publications

• Research Article   
  Next-Generation Rigid Scaffolds: Lessons from Prismane and Twistane
  Author(s): Valery M. Dembitsky* and Alexander O. Terentev
  
  Rigid polycyclic hydrocarbons represent a unique class of molecular scaffolds whose constrained three-dimensional architectures offer distinct advantages for chemical biology and drug design. Among these, prismane and twistane occupy an exceptional position due to their extreme rigidity, high geometric strain, and well-defined topological features. In contrast to classical rigid frameworks such as adamantane, prismane and twistane remain largely unexplored in biomedical research, despite their potential to access novel regions of pharmacological space.This review provides a comprehensive analysis of prismane- and twistane-based model compounds bearing diverse functional groups and halogen substituents, with a particular focus on their predicted biological activities evaluated using the Prediction of Activity Spectra for Substances (PASS) algorithm. By systematically comparing these sc.. Read More»
  

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