Journal of Applied Engineering Education(JAEE)
ISSN: 3066-3679 | DOI: 10.33140/JAEE
Alejandro Jesus Bermejo-Valdes
Riojan Health Service, Emergency Service 061, Piqueras 98, 26006, Logroño, La Rioja, Spain
Publications
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Research Article
Ciliary Dysfunction Secondary to COVID-19. Explanation of the Pathogenesis from Analysis of Human Interactome with SARS-CoV-2 Proteome
Author(s): Alejandro Jesus Bermejo-Valdes*, Alexander Ariel Padron-Gonzalez and Jessica Archer Jimenez
Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is sufficient experimental evidence to confirm that SARS-CoV-2 infection produces states of ciliary and flagellar dysfunction. However, these studies are unable to explain the observed effects molecularly, because they lack a sufficient understanding of the interaction between human proteins and virus proteins. Using the physical-chemical study of the human interactome in interaction with the SARS-CoV-2 proteome, we found evidence of interactions to explain the experimental effects from a molecular perspective. We found that ten viral proteins interact with key components in the maintenance of the molecular structure of axoneme. Additionally, we evaluated the pulmonary and extrapulmonary pathogenesis of COVID-19 from the point of view of ciliar.. Read More»