Journal of Clinical & Experimental Immunology(JCEI)

Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA

Publications

• Review Article   
  Prospect of Muscle-Building Supplement HMB in Alzheimer’s Disease
  Author(s): Abhiram Uppalapati*, Ahiri Vishnubhotla* and Kalipada Pahan
  
  Alzheimer’s disease (AD) is the most common progressive and irreversible neurodegenerative disorder in humans that affects memory, thinking and behavior. Impairment in synaptic plasticity is one of the hallmarks in AD, with most of the impairment occurring in the hippocampal region, a key part of the brain for memory and learning. Therefore, the upregulation of hippocampal plasticity is critical to remediate the progression of AD and preserve memory formation and cognitive functions. Recent studies have described β-hydroxy-β-methylbutyrate (HMB), a body building supplement commonly used by athletes, as a candidate molecule for improving hippocampal plasticity. Clinically, AD is characterized by the abnormal accumulation of beta amyloid (Aβ) plaques, coupled with intracellular aggregates of hyperphosphorylated tau protein. In addition to enhancing hippocampal plast.. Read More»
  

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