Surveillance of the Impact of Antimicrobial Resistant Infections in Immunocom-promised Children’s Therapy: A Systematic Review

Abstract

Danielle Domo, Ivo Ngundu Woogeng, Marilena Agosta, Marta Argentieri, Venere Cortazzo, Barbara Lucignano, Livia Mancinelli, Giordana Mattana, Manuela Onori, Laura Pansani, Annamaria Sisto, Carlo Federico Perno and Paola Bernaschi

Background: Antimicrobial resistance (AMR) is a global problem. For many reasons, resistant bacteria do not cease to emerge and re-emerge. The impact of AMR on patient therapy is still limited in literature, but there is still much to do, mainly in pediatric settings. It is vital to assess the necessity of observing the impact of such infections on the clinical care trends to which some kids may already be subject, strengthening, improving, and, where necessary, implementing new age policies and regulations that may help contain the spread of AMR.

Method: We performed a yearlong review of literature on antimicrobial resistance in paediatrics immunosuppressed patients until September 2022. We draw up a protocol to which we adhered rigorously, following the prescribed including and excluding criteria.

Results: From the 110 articles finally selected following the PRISMA workflow diagram, from which 29% of them were in the majority randomized controlled trials studies, the remaining selection ranged from case controls to cohort studies, systematic reviews, held before and after reports trials, matched case-control and placebo reports trials and few not reported research article types (15%).

Conclusion: The process yielded the confirmation that there is good evidence of the lethal effect of resistant microbiological infections in immunocompromised children in and out of hospitals. What needs to be added is practical evidence of such damage to the patient and the public health sector, which can be conquered through well-programmed cohort-based studies.

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