Renal Effects of Sulfated Polysaccharides from the Seaweed Gracilaria Cornea

Abstract

Noroes, T.B.S*, Monteiro, H.S.A, JORGE, A.R.C and Silva

The snakes from the genus Bothrops are responsible for most part of the ophidic accidents in Brazil and Bothrops atrox represents one of these species. The poisoning by these snakes leads to systemic alterations, and is responsible for preliminary cause of death after the ophidic accident. This study aimed to evaluate the pharmacological effects of the snake venom Bothrops atrox (VBA). This work looked at the actions of VBA on the renal perfusion. After renal perfusion, the kidneys were subjected to histological analysis. All parameters studied were analysed by ANOVA and Student t-test, p< 0,005. The VBA promoted a significant decrease in perfusion pressure, and in renal vascular resistance. However, the urinary flow and the glomerular filtration rate increased significantly. The perfused kidneys histological alterations were discrete. There was no investigation of the participation of Oxide nitric in the efeitos pressóricos of VBA in the system de perfusão renal, in a living experiment. There was an increase in the production of nitrite in the blood of the treated animals with VBA. There was made a pharmacological blockade with L-Name and the increase in the production of nitrite were abolished. Through these results we concluded that VBA causes alteration in the renal parameters and induces increase in the production of oxide nitric.

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