Protective Action of Aegeline and Quercetin Against Streptozotocin-Induced Diabetic Nephropathy

Abstract

Mihir Y. Parmar, Sharma Devanshi Niranjan, Kautuk Shah, Salaj Khare, Imtiyaz Baghban, Zalak Dave,Kaish Pathan,Palak Landge, Paswan Praveen Kumar and Parmar Bhumika J

Background: Diabetic nephropathy (DN) is a major cause of end-stage renal disease characterized by persistent albuminuria, declining glomerular filtration rate, and increased cardiovascular mortality. This study investigates the protective effects of Aegeline and Quercetin against streptozotocin (STZ)-induced diabetic nephropathy.

Methods: STZ was used to induce diabetes in Wistar rats. Treated groups received Aegeline, Quercetin, or their combination. Physical parameters (body weight, food, and water intake), biochemical markers (blood glucose, serum insulin, %HbA1c), renal parameters (albumin, creatinine, uric acid, cholesterol, total protein, triglycerides), oxidative stress markers (SOD, GSH, CAT, MDA), and histopathological evaluations were assessed.

Results: Treatment with Aegeline and Quercetin significantly ameliorated hyperglycemia, improved insulin sensitivity, restored renal parameters, reduced oxidative stress, and mitigated histopathological alterations in kidneys compared to diabetic control.

Conclusion: Aegeline and Quercetin exhibit substantial nephroprotective effects against diabetic nephropathy, indicating potential therapeutic roles

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