Potential Carcinogenicity with Prolonged Use of Proton Pump Inhibitors as Gastric Acid Suppressants

Abstract

Amit Sharma, Vikram Vohra

The mainstay of the treatment of Peptic Ulcer Disease (PUD), Gastro-esophageal reflux Disease (GERD) and other forms of gastritis including ulcers caused by non-Steroidal anti-inflammatory drugs (NSAID), is the group of Drugs known as Proton Pump Inhibitors (PPI). PPI include Omeprazole, Pantoprazole, Rabeprazole, Esomeprazole etc. The action is exerted by suppression of acid production in the stomach by blocking the gastric H+K+-ATPase. They are effective also in the prevention of PUD and form an integral part in the eradication of Helicobacter Pylori along with antibiotics from the gastric-duodenal part of the alimentary Canal [1]

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