Pathohistological and Immunohistochemical Analysis, Differential Diagnosis, Prognosis and Complex Treatment in a Rare Lymphoepithelioma-Like Breast Cancer

Abstract

We present a 78-year-old woman with a rare neoplasm of the right mammary gland – Lymphoepithelioma-like carcinoma (LELC). Lymphoepithelioma-like carcinoma is an undifferentiated neoplasm, consisting of malignant epithelial cells on the background of lymphocytes. Pathomorphological features and immunohistochemical (IHC) analysis determines the rare pathohistological variant of breast cancer . This clinical case of lymphoepithelioma-like breast cancer is the 34th published in medical literature in English. In the discussion, we emphasize the importance of immunohistochemical analysis to assess the differential diagnosis with other benign and malignant breast tumors . Lymphoepithelioma-like breast cancer is an extremely malignant epithelial neoplasm with an unfavorable prognosis, requiring complex oncological treatment.

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